Mastoparan-induced programmed cell death in Chlamydomonas

Mastoparan-induced programmed cell death in Chlamydomonas

Mastoparan-induced pro­grammed cell death in Chlamydomonas

Under stress-promoting con­di­tions uni­cel­lu­lar algae can undergo pro­grammed cell death (PCD), but the mech­an­isms are poorly under­stood. Yordanova et al. expose Chlamydomonas rein­hardtii to the G-protein activ­ator mas­topa­ran (MP) and find that cells express sev­eral fea­tures of nec­rosis and vacu­olar cell death, accom­pan­ied by nuc­lear con­dens­a­tion and DNA frag­ment­a­tion. Depending on the physiolo­gical state of the cells and their sens­it­iv­ity to MP, a por­tion of cells undergo early PCD through a pro­cess not medi­ated by capase, whereas other cells die at a slower pace that involves capase-like path­ways. The find­ings thus reveal novel ele­ments of the cell death pro­cess in algae and sug­gest that algal PCD may take dif­fer­ent forms and pro­ceed through dif­fer­ent pathways.

Annals of Botany Office.

The Annals of Botany Office is based at the University of Leicester.